| Benzodiazepine | Onset of Action2 | Peak Onset (hrs) | Half-life parent (hrs) | Half-life metabolite (hrs) | Comparative Oral Dose |
| Long Acting | |||||
| Diazepam1 (Valium®) | Rapid (po, IV) | 1(po) | 20-50 | 3-100 | 5 mg |
| Intermediate Acting | |||||
| Alprazolam1 (Xanax®) | Int. | 0.7-1.6 | 6-20 | - | 0.5mg |
| Clonazepam1 (Rivotril®) | Int. | 1-4 | 18-39 | - | 0.25mg |
| Lorazepam1 (Ativan®) | Int. (po), Rapid (sl, IV) | 1-1.5 (po) | 10-20 | - | 1mg |
| Short Acting | |||||
| Midazolam1 (Versed®) | Most Rapid IV | 0.5-1 (IV ) | 1-4 | - | - |
2 Rapid onset = within 15 minutes, Intermediate = 15-30 minutes, Slow = 30-60 minutes
References:
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