Biotin Availability

The characterization of biotin as a vitamin was based on the discovery that biotin deficiency causes a clinical syndrome, which is mediated by deficiencies of several carboxylase enzymes.
Sources — Biotin can be found in a variety of plants but is found in highest levels in the liver, egg yolk, soybean products, and yeast

Deficiency

was first noted in patients who were on long-term parenteral nutrition prior to routine biotin supplementation. It is now reported only rarely.
Consumption of large amounts of raw egg whites (which contain avidin, a substance that binds to biotin and prevents its utilization), can also lead to biotin deficiency.
secondary biotin deficiency can occur due to lack of a specific enzyme (biotinidase), which is required for recycling of biotin
classic clinical manifestations of biotin deficiency include dermatitis around the eyes, nose and mouth, conjunctivitis, alopecia, and neurological symptoms, including changes in mental status, lethargy, hallucinations, and paresthesias
Other manifestations may include myalgia, anorexia, and nausea

Requirements:

The recommended intake for biotin is expressed as Adequate Intake (AI) rather than Recommended Dietary Allowance (RDA), indicating that there is not adequate data to specify the percentage of individuals whose requirement is met by this intake

Choice of Therapy

No medication available in Hospital Keningau (not a constituents of oral and IV multivitamins)
No readily available formulation in FUKKM
Recommended to use infant formulas enriched with biotins