Availability:
- Tranexamic Acid Capsule 250mg
- Tranexamic Acid injection 100mg/ml
Rationale
- 90% excreted by glomerular filtration in 24h (IV)
- Thus there is a risk of accumulations in renal impaired patients
- Overdose symptoms include dizziness, headache, nausea, vomiting and diarrhoea. Orthostatic symptoms and hypotension may occur.
Renal Dose Adjustment:
- Dose and its adjustments are also dependent on the indications
Oral
| GFR (ml/min) | Dose |
| 30-60 | 1-1.5g , BD-TDS |
| 10-30 | 1-1.5g , OD |
| <10 , Dialysis | 0.5-1g , OD |
| Serum Creatine (mmol/L) | Dose |
| 120-250 | 15mg/kg BD |
| 250-500 | 15mg/kg OD |
| >500 | 7.5mg/kg OD |
Intravenous
| Serum Creatine (mmol/L) | Dose |
| 120-250 | 10mg/kg BD |
| 250-500 | 10mg/kg OD |
| >500 | 10mg/kg every 48h OR 5mg/kg OD |
*Based on adjustment in dose for tooth extraction in patients with hemophilia
References:
- http://www.globalrph.com/tranexamic_acid_dilution.htm
- The Renal Drug Reference Guide, First Edition.
- Product Leaflets
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