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Rationale:
  • Budesonide and beclometasone dipropionate are considered equivalent on a microgram for microgram basis (1:1 dose ratio).
  • However, the type of hydrofluoroalkane (HFA)-propelled beclometasone dipropionate (pMDI) (Qvar, IVAX) (available in Hospital Keningau) delivers beclometasone dipropionate in extra fine particles so that more is deposited in the lungs, leading to a 2:1 dose ratio with the CFC budesonide/beclometasone dipropionate devices
  • Half the dose of fluticasone propionate, mometasone furoate or ciclesonide in micrograms is equivalent to a given dose of budesonide/beclometasone dipropionate (2:1 dose ratio).

References:
  1. GINA 2017
  2. Drug Information Leaflet
  3. https://www.nice.org.uk/guidance/ta138/chapter/3-the-technologies
  4. http://www.bpac.org.nz/2017/ics.aspx

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