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Availability:
  • Ipratropium Bromide 0.5mg & salbutamol 2.5mg
  • Dosage (adults & > 12 years)
  • 1 respule 3-4 times daily
  • One unit dose (respule) provides prompt relief in most cases.
  • In severe cases, if an attack has not been relieved by one respule, two respules may be required
Administration
  • respules should be used undiluted.
Pharmacokinetic
  • For inhaled ipratropium is minimal, maximal responses usually develop over 30 to 90 minutes, lasting for four to six hours. 
  • The elimination half-life of ipratropium is approximately 3 to 4 hours after inhalation.
    For Salbutamol significant bronchodilation occurs within minutes of inhalation of a therapeutic dose, persisting for three to four hours. 
  • The elimination half-life of salbutamol is estimated to range from 4 to 6 hours.
Reference:
  • Duolin Respule Product Information Leaflet

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  1. Duolin Respules is a combination medicine which is used for treating chronic obstructive pulmonary disorder (COPD). The medicine helps control the symptoms such as shortness of breath, wheezing, breathing difficulties, chest tightness and cough etc. The medicine takes a few days to show its effect. Duolin Respules is a prescription medicine and should be taken only when your doctor prescribed it. To get the benefit of this drug you are required to follow a correct inhaler technique otherwise, the medicine will not work.

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  2. Duolin Respules is given to get relief from cough and wheezing; it is also given to the patient who feels shortness of breath, in short, Duolin respules is given for treating COPD (chronic obstructive pulmonary disorder). Duolin Respules is a prescription drug that comes in a combination of two medicines (i.e. Levosalbutamol and Ipratropium). The medicine works by relaxing muscles in the airways. Your doctor will suggest how often you have to take this medicine. Duolin Respules are commonly given through inhaler.

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