Availability in Hospital Keningau:
- IV Acyclovir 250mg
Indication:
- Treatment and prophylaxis of herpes simplex in immunocompromised, severe initial genital herpes and Varicella -Zoster.
Skin Reactions
- According to previous report, adverse cutaneous reactions have been reported with all routes of administration
- Local inflammation or phlebitis at the injection site are well-known dermatologic reactions of intravenous acyclovir therapy.
- Common dermatological reactions include alopecia, erythema multiforme, photosensitive rash, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, and urticaria
- Severe local inflammatory reactions, including tissue necrosis, have occurred following infusion of acyclovir into extravascular tissues
- There are rarely reported on acyclovir infusion induced the bullous.
- But recently, Yorulmaz et al., 2015, present a case of localized bullous eruption and phlebitis associated with intravenous acyclovir treatment in a patient with metastatic breast cancer
- Others case reported of acyclovir infusion induced bullous which mostly appeared after 10-15 days of infusion.
References:
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3271519/
- https://www.ncbi.nlm.nih.gov/pubmed/26911608
- https://aidsinfo.nih.gov/drugs/8/acyclovir/39/professional
- http://www.jacionline.org/article/S0091-6749(16)31818-8/fulltext
- Formulary Ubat KKM August, 2017
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