Availability
- Injection Diclofenac Injection 75mg/3ml (Dicloran)
Route of administration
- Based on product information, mode of administration specified is Intramuscular
- No information on administration via other routes
Administration via Intravenous Route
- There are several products available that can be given as IV
- However these products are specifically made for such routes / should not be interchanged
- Complications of wrong administration
- Not much information on effect and management of IM injection administered as IV
- Based on several case reports of administration intravenously into arterial route, symptoms seen are gangrene and burning sensations.
- Vasospasm, intravascular thrombosis, chemical endoarteritis are the proposed pathophysiological mechanism
- Intravenous drug administration has been associated with the occurrence of Thrombophlebitis
- Rare adverse events (based on IV diclofenac): cannula site reaction, infusion site discomfort or burning, injection site stinging, or pyrexia
Contraindications for IV Route
- Concomitant NSAID or anticoagulant use (including low dose heparin).
- History of haemorrhagic diathesis, a history of confirmed or suspected cerebrovascular bleeding.
- Operations associated with a high risk of haemorrhage.
- A history of asthma.
- Moderate or severe renal impairment (serum creatinine >160μmol/l).
- Hypovolaemia or dehydration from any cause
References:
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