Corticosteroid in Autoimmune Hemolytic Anemia

Corticosteroid in autoimmune hemolytic anemia can stop an immune system from, or limit its ability to, make antibodies (proteins) against red blood cells.
There is a few available regimens recommended for corticosteroid dosing administration.

Journal of the European Hematology Association :

Prednisolone

Initial dose of 1.0–1.5 mg/kg/day for 1–3 weeks until hemoglobin levels greater than 10 g/dL are reached
If none or minimal improvement is observed in the third week, this therapy is assumed to be ineffective
After stabilization of hemoglobin, prednisone should be gradually and slowly tapered off at 10–15 mg weekly to a daily dose of 20–30 mg, then by 5 mg every 1–2 weeks until a dose of 15 mg, and subsequently by 2.5 mg every two weeks with the aim of withdrawing the drug

Methylprednisolone

Intravenous methylprednisolone at 100–200 mg/day for 10–14 days or 250–1000 mg/day for 1–3 days

Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria:

Prednisolone

Initial dose of 1 mg/kg/d prednisolone is administered until a hematocrit of greater than 30% or a hemoglobin level greater than 10 g/dL (thus, not necessarily a complete normalization of hemoglobin is reached)
If this goal is not achieved within 3 weeks, second-line treatment is started because further improvement with steroid treatment is unlikely
Once the treatment goal is achieved, the dose of prednisolone is reduced to 20 to 30 mg/d within a few weeks
Thereafter, the prednisolone dose is tapered slowly (by 2.5-5 mg/d per month)
An alternate-day regimen by reducing the dose gradually to nil on alternate days may reduce the side effects of steroids

Netherlands the Journal of Medicine:

Prednisolone

1 mg/kg/day is started, and depending on the clinical response is tapered slowly
After stabilisation of the haemoglobin a scheme frequently used at our department is to taper prednisolone to a dosage to 20 mg/day in two weeks
If the haemoglobin level remains stable, dosage can further be reduced to 10 mg/day after a month
Thereafter, the steroid dosage can further be tapered and be stopped after two weeks

Uptodate:

Prednisolone

The recommended initial doses are quite high - 1 to 1.5 mg/kg per day of prednisolone
Doses in children are generally similar
A successful treatment manifest by a rising hemoglobin concentration, is usually seen within one to three weeks
Once remission has been achieved, the steroid dose must be tapered.
In children, this can be done quite rapidly since the disease process is often self-limited. In adults, tapering should be more gradual in an attempt to find the lowest dose that will maintain an adequate remission
The following tapering down schedule is found to be useful:

References

Netherlands the Journal of Medicine. ‘Autoimmune haemolytic anaemia – A practical guide to cope with a diagnostic and therapeutic challenge. Retrieved from http://www.njmonline.nl/getpdf.php?id=1045
Official Journal of the European Hematology Association. ‘Treatment of autoimmune hemolytic anemias’.Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181250/
Division of Hematology and Hemostaseology, Department of Medicine I, Medical University of Vienna, Vienna, Austria.’ How I treat autoimmune hemolytic anemias in adults’. Retrieved from http://www.bloodjournal.org/content/bloodjournal/116/11/1831.full.pdf?sso-checked=true
Uptodate. 'Warm autoimmune hemolytic anemia: Treatment'. Retrieved from https://www.uptodate.com.ezp.imu.edu.my/contents/warm-autoimmune-hemolytic-anemia-treatment