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Rationale

  • Lugol’s solution can be used to determine the need for biopsy of areas that are minimally abnormal
  • It binds to cells with high amounts of glycogen (normal squamous epithelium)
  • Lugol’s Positive (epithelium turns dark brown after application) – epithelium is mature squamous and does not need to be bipsied (unless suspicion is high)

Procedure

  • application to the cervix using cotton-tipped bud 
  • no specific volume indicated/minimal amount based on site
  • be done in a manner without abrading the surface epithelium, as HSIL lesions can detach from the underlying stroma relatively easily and peel away
  • Lesion margins, color, and vascular patterns are then assessed and graded, with biopsies taken from the areas that are judges as the most severe

References:

  1. 2002-04 ASCCP Section on the Cervix
  2. STANDARDIZEDPROCEDURE COLPOSCOPY (Adult, Peds).  UC San Diego Health
  3. http://screening.iarc.fr/colpochap.php?chap=5
  4. https://www.glowm.com/section_view/heading/Colposcopy/item/19

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