Rationale
- Lugol’s solution can be used to determine the need for biopsy of areas that are minimally abnormal
- It binds to cells with high amounts of glycogen (normal squamous epithelium)
- Lugol’s Positive (epithelium turns dark brown after application) – epithelium is mature squamous and does not need to be bipsied (unless suspicion is high)
Procedure
- application to the cervix using cotton-tipped bud
- no specific volume indicated/minimal amount based on site
- be done in a manner without abrading the surface epithelium, as HSIL lesions can detach from the underlying stroma relatively easily and peel away
- Lesion margins, color, and vascular patterns are then assessed and graded, with biopsies taken from the areas that are judges as the most severe
References:
- 2002-04 ASCCP Section on the Cervix
- STANDARDIZEDPROCEDURE COLPOSCOPY (Adult, Peds). UC San Diego Health
- http://screening.iarc.fr/colpochap.php?chap=5
- https://www.glowm.com/section_view/heading/Colposcopy/item/19
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